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Computational models of brain connectivity, coupled with machine learning algorithms, make it possible to infer neuronal disease mechanisms from non-invasive functional magnetic resonance imaging (fMRI) data in humans. This illustration shows how dynamic systems models can be used for reducing complex (high-dimensional) brain activity data to a simple (low-dimensional) and mechanistically interpretable representation (Brodersen et al., PLoS Comput. Biol. 2011). Please also see the summary on ETH Life.

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